Day 1
Sunday, September 24th, 2017
Registration
Opening of the Symposium
20.30 Keynote Lecture Miguel A. de Pedro (Centro de Biologia Molecular “Severo Ochoa” CSIC-UAM)
Murein: A biosphere homeostatic factor?
Day 2
Monday, September 25th, 2017
Session 1. Building the wall (Chair: Rut Carballido-Lopez, INRA, France)
09.00 – 09.30 Tom Bernhardt (Harvard University, Cambridge, MA, USA) NlpD links cell wall remodeling and outer membrane invagination during cytokinesis in Escherichia coli
09.30 – 10.00 Ethan Garner (Harvard University, Cambridge, MA, USA)
Insights into the mechanisms determining the width and growth rate of B. subtilis
10.00 – 10.15 Short talk 1 Victoria A Lund (Sheffield University, UK) Distribution and coordination of cell wall peptidoglycan insertion in S. aureus
10.15 – 10.30 Short talk 2 Karina Ramijan Carmiol (Leiden University, The Netherlands) Reversible metamorphosis in a bacterium
10.30 Coffee break 11.00 – 11.30 Seok-Yong Lee (Duke University, Durham, NC, USA) Crystal structure of the MOP flippase MurJ
11.30 – 12.00 Tanneke de Blaauwen (University of Amsterdam, The Netherlands) Role of MurJ in peptidoglycan synthesis
12.30 Lunch Afternoon break
16.30 – 17.30 Coffee & Posters Session 2. Modifying the Wall (Chair: Cécile Morlot, Institut de Biologie Structurale, Grenoble, France)
17.30 – 18.00 Waldemar Vollmer (Newcastle University, UK) Multiple protein-protein interactions govern peptidoglycan synthesis and hydrolysis in E. coli
18.00 – 18.30 Michel Arthur (Centre de Recherche des Cordeliers, Université Paris VI, France)
Analysis of the diversity of ß-lactam-interacting enzymes provides insight into the potential and limits for evolution toward resistance
18.30 – 18.45 Short talk 3 Mijoon Lee (University of Notre Dame, Notre Dame, IN, USA) Deciphering the nature of enzymatic modifications of bacterial cell wall
18.45 – 19.00 Short talk 4 Yen-Pang Hsu (Indiana University, Bloomington, IN, USA) Elicidating post-septational peptidoglycan (PG) remodeling using fluorescent D-amino acids
19.00 – 19.30 Juan Hermoso (Instituto de Química Física Rocasolano – CSIC, Madrid, Spain) Structural insigths on regulation of peptidoglycan recycling and antibiotics resistance in P. aeruginosa
19.30 – 20.00 Suzanne Walker (Harvard University, Cambridge, MA, USA) Another brick in the wall
Day 3
Tuesday, September 26th, 2017
Session 3. Interactions with the wall (Chair: Ivo G Boneca, Institut Pasteur, France) 09.00 – 09.30 K Mark Coggeshall (University of Oklahoma, Oklahoma city, OK, USA) Anthrax peptidoglycan activates both intrinsic and extrinsic coagulation pathways to cause hemostatic and DIC in non-human primates
09.30 – 10.00 Andrea Wolf (Cedars-Sinai Medical center, Los Angeles, CA, USA) The peptidoglycan-derived sugar, N-acetylglucosamine, modulates the glycolytic enzyme hexokinase leading to inflammasome activation
10.00 – 10.15 Short talk 5 Sónia Castanheiro (Centro Nacional de Biotecnologia – CSIC, Madrid, Spain) A novel penicillin-binding protein contributes to Salmonella infection in eukaryotic cells
10.15 – 10.30 Short talk 6 Catherine Werts (Institut Pasteur, Paris, France) LipL21 lipoprotein binding to peptidoglycan as a peculiar mechanism of Leptospira interrogans escape from NOD receptors signaling
10.30 Coffee break 11.00 – 11.30 Julien Royet (Institut de Biologie du Développement de Marseille, Université Aix-Marseille, France) When PGN modifies fly behavior by acting on octapaminergic neurons
11.30 – 12.00 Rochellys Diaz Heijtz (Karolinska Institut, Stockholm, Sweden) Bacterial peptidoglycans as novel signaling molecules from microbiota to brain 12.30 Lunch Afternoon break or
14.00 – 16.00 Sheba Agarwal-Jans (Microbiology and Mycology Publisher, Elsivier) Workshop “Getting your article published – Insights to what Editors, authors and readers want”
16.30 – 17.30 Coffee & Posters Session 4. Inhibition of the wall (Chair: Natalie Strynadka, Univ British Columbia, Canada)
17.30 – 18.00 Malcolm Page (Basilea Pharmaceuticals, Switzerland) Strategies and challenges in cell wall inhibition
18.00 – 18.30 Jeff Errington (Newcastle University, UK) Lysozyme can counter ß-lactam killing by promoting the emergence of L-form bacteria
18.30 – 18.45 Short talk 7 Karin Schubert (Ludwig-Maximilians University, Munich, Germany) Influence of anti-tuberculosis drugs on cell wall synthesis in Corynebacterineae
18.45 – 19.00 Short talk 8 Paulo Vinicius da Mata Madeira (Laboratório Nacional de Biociências, Campinas, Brasil) Identification of new molecules capable to avoid transpeptidation
19.00 – 19.30 Eric Brown (McMaster University, Hamilton, Ontario, Canada) Pushing the envelope in Gram-negative bacteria
19.30 – 20.00 Folkert Reck (Novartis Institutes for Biomedical Research, Emeryville, CA, USA) LYS228, a novel monobactam to treat infections caused by multi-drug resistant Enterobacteriaceae 20.30 Cocktail and Gala Diner
Day 4
Wednesday, September 27th, 2017
Session 5. Regulating the Wall (Chair: David Roper, Univ Warwick, UK)
09.00 – 09.30 Christophe Grangeasse (Molecular Microbiology and Structural Biochemistry, University Lyon 1, France) Disentangling the role of PASTA domains in cell division of Steptococcus pneumoniae
09.30 – 10.00 Andrea Dessen (Institut Biologie Structurale, Grenoble, France) Structural insights into PBP interactions in cell wall formation and defense
10.00 – 10.15 Short talk 9 Eleni Karinou (Imperial College London, UK) Elucidating the physiological role of lipoteichoic acid in Staphylococcus aureus
10.15 – 10.30 Short talk 10 Sara Hernandez (Umea University, Umea, Sweden) Regulatory crosstalk between peptidoglycan biosynthesis and recycling in Vibrio
10.30 Coffee break
11.00 – 11.30 Andy Lovering (University of Birmingham, UK) Structural basis for elements of peptidoglycan modification by the bacterial predator Bdellovibrio
11.30 – 12.00 Malcolm Winkler (Indiana University, Bloomington, IN, USA) Static and dynamic measurements of rotational movement of PBPs, FtsZ and divisome proteins in Streptococcus pneumoniae
12.30 Lunch Afternoon break
16.30 – 17.30 Coffee & Posters Session 6. Coordinating the Wall (with the cell cycle) (Chair: Lori Burrows, McMaster Univ, Canada)
17.30 – 18.00 Petra Levin (Washington University, St. Louis, MO, USA) The cell envelope: a dynamic link between inside and outside
18.00 – 18.30 Jaan Mannik (University of Tenneessee, Knoxville, TN, USA) Multiple layers of coordination provide reliable partitioning of chromosomes during E. coli cell division
18.30 – 18.45 Short talk 11 Manuel Pazos (Newcastle University, UK) ZipA interacts with peptidoglycan synthases during early stages of Escherichia coli cell division
18.45 – 19.00 Short talk 12 Adrián Izquierdo Martínez (University of Marburg, Germany) Coordination of peptidoglycan hydrolysis during cell division in C. crescentus
19.00 – 19.30 Lori Burrows (McMaster University, Hamilton, ON, Canada) Type IV pilus assembly systems are preinstalled during cell division
19.30 – 20.00 Mariana Pinho (Instituto de Tecnologia Química e Biológica, Oeiras, Portugal) Recruitment of peptidoglycan synthesis to midcell drives cell envelope constriction
20.00 Closing of the meeting and selection of the next venue.
And some photos…
